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The original Harding lab publications described rat studies showing: Improvement in cognitive performance in Morris water maze tasks (Wright et al

Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia

But this comes at a cost

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Substrates include xenobiotic electrophiles (drugs, environmental toxins, carcinogens), endogenous electrophiles (,-unsaturated aldehydes, quinones), and reactive intermediates from Phase I metabolism